Lymphocyte immunization therapy (LIT) is yielding successful results in infertile couples who cannot achieve pregnancy despite persistent efforts. Recent research in immunology suggests that a large portion of unexplained infertility cases may be linked to immune system disorders, many of which can be prevented with new treatment methods.
The immune system is a complex defense mechanism. It categorizes proteins as familiar or foreign and attacks those it deems foreign. A simple example is the formation of antibodies when microbes enter the body.
There are five categories of immune problems that lead to pregnancy loss, infertility, and IVF failure. Miscarriages occur when the mother's body reacts against the tissues of the baby and the placenta. Reactions against fetal proteins can prevent pregnancy or lead to miscarriage.
Paternal Lymphocyte Immunization (PLI) in IVF
This method, also called the Lymphocyte Vaccine, has been used since 1978 to treat recurrent miscarriages. Today, it is successfully applied in cases of unexplained infertility and persistent IVF failure. We aim to stimulate the formation of 'blocking antibodies' in the mother to suppress cells that harm the developing fetus.
Lymphocytes are isolated from the father's blood sample via centrifugation and injected subcutaneously into the mother's forearm at four points. It is recommended to apply this three times before IVF and twice after pregnancy is achieved. Before preparation, the father is screened for Hepatitis and HIV.
The vaccine has no harmful effects on the mother or the baby. No increase in congenital anomalies or developmental delays has been observed in babies born after this treatment. It does not increase the risk of autoimmune diseases.
